Relevant Scientific Publications.
IAVI and Scripps Research have a successful history of discovering highly broad and potent neutralising antibodies against HIV and have built an antibody discovery platform that is readily applicable to other disease areas. The articles highlighted in this section provide the context that has informed the SRPNTS approach towards generating humanised monoclonal antibodies for eventual next-generation snakebite therapy(ies).
Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows. Sok D, Le KM, Vadnais M, Saye-Francisco KL, Jardine JG, Torres JL, Berndsen ZT, Kong L, Stanfield R, Ruiz J, Ramos A, Liang CH, Chen PL, Criscitiello MF, Mwangi W, Wilson IA, Ward AB, Smider VV, Burton DR. Nature. 2017 Aug 3; 548(7665):108-111. doi: 10.1038/nature23301.
SRPNTS researchers based at LSTM, N-SRIC, K-SRIC, and IISc have led the snakebite field in generating key data assessing snake venom toxin proteomes, transcriptomes, as well as the efficaciousness of existing commericial antivenoms. The articles highlighted here capture the work and contributions made by our SRPNTS researchers prior to joining and during our partnership.
Signs, symptoms and treatment of envenomation. Boyer, L., Alagón, A., Fry, B.G., Jackson, T.N.W., Sunagar, K. and Chippaux, J.P. Venomous Reptiles and Their Toxins: Evolution, Pathophysiology, and Biodiscovery; Fry, BG, Ed, pp.32-60. 2015.
Analysis of camelid IgG for antivenom development: Immunoreactivity and preclinical neutralisation of venom-induced pathology by IgG subclasses, and the effect of heat treatment. Cook DA, Samarasekara CL, Wagstaff SC, Kinne J, Wernery U, Harrison RA. Toxicon. 2010 Sep 15;56(4):596-603. Doi: 10.1016/j.toxicon.2010.06.004.